Pharmacokinetics and Toxicology

Preclinical PK, ADME, formulation, and in vivo toxicology, with on-site bioanalysis

We design and run PK and toxicology studies across rodent and other species. Formulation support and on-site analysis keep turnaround fast, and studies are tailored to the question, from a single readout to a full report.

Pharmacokinetics and ADME

Pharmacokinetics describes how a drug is absorbed, distributed, metabolized, and eliminated. Knowing the PK is essential to setting a dosing regimen and staying within the therapeutic window. We have established protocols across a wide range of study designs, with sample analysis on our own site. Our offering includes:

PK, formulation, and biodistribution studies in mouse, rat, guinea pig, hamster, rabbit, and ferret

Custom study design to fit your program

Support across the full process, from formulation to sample analysis

Administration routes

Oral (solution, suspension, or drug-filled capsule), intravenous, intramuscular, subcutaneous, intraperitoneal, intracerebroventricular, and intranasal.

Study design

Formulation tests to identify suitable vehicles before the study

Single or repeat dose, or continuous infusion

Tissue collection with or without perfusion for biodistribution

Sampling of bile, urine, and cerebrospinal fluid

A formal study report

Bioanalysis

Our on-site bioanalytical facility analyzes samples from in-house studies and from other facilities, with rapid turnaround.

In vivo toxicology

Before a candidate advances to the clinic, preclinical testing has to show it is both effective and safe. For the safety side, in vivo toxicology studies remain the standard. They assess general tolerability, organ-specific effects, and hematological changes, and help estimate the therapeutic window between an effective dose and the onset of toxic effects. Rodents suit this work, since the data are reproducible and well referenced and small body size keeps the amount of compound needed low. Our offering includes: